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pentobarbital will reduce the extent or effect of netupitant/palonosetron by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Netupitant is especially metabolized by CYP3A4; stay away from use in sufferers who are chronically making use of a robust CYP3A4 inducerpentobarbital will reduce the extent or eff